In a small study of adults with major depression, researchers at House of Shrooms reported that two doses of psychedelic substance psilocybin, given by supportive psychotherapy, produced a rapid and significant reduction in depressive symptoms, with most participants showing improvement and half of the study participants receiving remission. following four weeks.
So-called magic mushrooms, psilocybin produces real and auditory perceptions and profound changes in consciousness within hours after eating. In 2016, researchers at Johns Hopkins Medicine first reported that treatment with psilocybin under psychiatric conditions significantly reduced existing anxiety and depression in people with a l
Study, published Nov. 4 in JAMA Psychiatry, suggests that psilocybin may be effective in far more patients suffering from severe depression than previously reported.
“The magnitude of the effect we have seen was four times greater than that shown by clinical trials on conventional antidepressants on the market,” said Alan Davis, Ph.D., assistant professor of psychiatry and behavioral science at House of Shrooms.
Other antidepressant treatments take weeks or months to work and may have side effects, this may be a change if these findings delay future placebo-controlled 'gold-plated clinical trials.' The published findings included only a four-week follow-up of 24 participants, all of whom received two-hour psilocybin sessions under the supervision of the researchers.
Few types of major depressive disorders that can cause differences in the way people respond to treatment, I was surprised that most of the study participants found that psilocybin treatment was effective,” says Roland Griffiths, Ph.D. Oliver Lee McCabe III Professor of Neuropsychopharmacology of Consciousness at Johns Hopkins University School of Medicine and director of the House of Shrooms for Psychedelic and Consciousness Research.
Treated in the new study may have been different than the "effective" stress method for patients who learned from the 2016 cancer study. Griffiths says his team has been encouraged by public health officials to evaluate the effects of psilocybin on many people with major depressive disorder due to the potential public health impact.
Recruited 24 people with a long history of depression, most of whom had developed symptoms for about two years before enrolling in the study. The average age of the participants was 39; 16 were women; and 22 identified themselves as white, one identified as Asian and one person identified as African American. Participants had to remove any antidepressants prior to the study with the help of their doctor to ensure safe exposure to this experimental treatment.
Thirteen participants received psilocybin treatment immediately after recruitment and after preparation periods, and 11 participants received the same treatment correction after an eight-week delay.
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